TDMR Europe Seminar – Diabetes Remission: Maintenance after weight loss with total diet replacement

Posted On: 22nd March 2022

Tuesday 12th April 2022 14:00-15:30 BST; 15:00-16:30 CEST; 16:00-17:30 EEST

European countries face levels of obesity and diabetes that will overwhelm capacity for healthcare provision. Weight loss has been recognised as the key component for diabetes prevention and key to effective diabetes remission.  A recent review (ref1) concluded that the best way to achieve the initial weight loss was with total diet replacement but much needs to be learned about effective weight loss maintenance.  Dietary glycaemic index has been an important part of dietary management of diabetes for some time and recent evidence from the EU funded PREVIEW trial (ref2) indicates low GI/low GL diet facilitated maintenance of weight loss and lower blood glucose. Clinical and public health guidelines are in the process of being reviewed.  All European countries require effective programmes for diabetes prevention, diabetes remission and obesity prevention and reduction.

The aim of the seminar is to review evidence for the requirements for weight maintenance after weight loss with Total Diet Replacement (TDR).

The evidence for achieving diabetes remission with diet and lifestyle will be reviewed and the timetable for forthcoming new guidelines will be indicated. Barriers to successful weight loss maintenance and remission will be described as well as potential solutions.  The evidence for use of low GI/low GL (low glycaemic index and low glycaemic load) diets in improving weight maintenance in the PREVIEW trial will be summarised and the potential benefits of low GI/low GL diets in diabetes management, particularly in Southern Europe will be discussed.

Speakers in the seminar will be:

  • Professor Mike Lean, University of Glasgow, Scotland and Principal Investigator of the DiRECT diabetes remission clinical trial;
  • Professor Gary Frost, Imperial College London, inventor with colleagues of inulin-propionate and lead investigator of studies on dietary factors in weight management;
  • Professor Elena Philippou, University of Nicosia, Cyprus and authority on diet in Southern Europe and on glycaemic index in dietary management.

The seminar will be chaired by Dr Anthony Leeds, Frederiksberg Hospital Copenhagen and University of Glasgow and chair of TDMR Europe who said ‘I’m delighted that we’re now able to offer our fourth web seminar on issues relating to use of total diet replacement in achieving enough weight loss to secure diabetes remission.  Weight maintenance remains a challenge, but solutions will be presented and discussed.’

Participation is free, but registration is essential.

Please make sure you register for the webinar here

Ref 1: Churuangsuk C et al. Diets for weight management in adults with type 2 diabetes: an umbrella review of published meta-analyses and systematic review of trials of diets for diabetes remission. Diabetologia 2022; 65: 14–36 doi: 10.1007/s00125-021-05577-2.

Ref 2: Zhu, al. Dose-dependent associations of dietary glycemic index, glycemic load, and fiber with 3-year weight loss maintenance and glycemic status in a high-risk population: A secondary analysis of the diabetes prevention study preview. Diabetes Care 2021; 44(7): 1672–1681

Information about previous seminars can be found at:

Reducing future risk: Obesity co-morbidities and nutritional status’  The index page is at:

‘Proven facts versus popular myth about weight loss with TDR’, held on 14th April 2021.  See:

‘Total Diet Replacement: exploring sustainable weight loss and health benefits, including diabetes remission and prevention’ was held on 27th October 2021 and brought together the three key speakers for three landmark trials: DiRECT (diabetes remission – Prof Mike Lean, University of Glasgow); PREVIEW (weight loss in a primary care setting – Dr Nerys Astbury, University of Oxford); and PREVIEW (diabetes prevention – Prof Jennie Brand Miller, University of Sydney). See the index page at: